SARS Corona Virus Monoclonal Antibody & RNAi Vaccine Cure.
SARS Corona Virus Molecular Biology.
Chemoattractans Extracellular Proteases Immunity Sys for Dipeptyl Peptidase 4 Cells
Immunity Process of Vero Cells.
Immunity Process of LLC-MK2 Cells.
Double Stranded RNA Killer Plasmid Replication in Saccharomyces Cerevisiae.
RNA Interference (RNAi)
Monoclonal Antibodies Inhibit SARS Infection by Different Mechanisms.
RNA Monoclonal Antibodies.
SARS coronavirus continues to cause sporadic cases of severe acute respiratory syndrome (SARS) in China. No active or passive immunoprophylaxis for disease induced by SARS coronavirus is available. We investigated prophylaxis of SARS coronavirus infection with a neutralising human monoclonal antibody in ferrets, which can be readily infected with the virus. Prophylactic administration of the monoclonal antibody at 10 mg/kg reduced replication of SARS coronavirus in the lungs of infected ferrets by 3·3 logs (95% Cl 2·6—4·0 logs; p<0·001), completely prevented the development of SARS coronavirus-induced macroscopic lung pathology (p=0·013), and abolished shedding of virus in pharyngeal secretions. The data generated in this animal model show that administration of a human monoclonal antibody might offer a feasible and effective prophylaxis for the control of human SARS coronavirus infection.